17th TNF conference 2019 – preliminary program

June 3rd, Arrival

any time after 2 pm, Registration

4:40 pm, Plenary session

Chairs: Gail Bishop and Domagoj Vucic

 
4:40 – 5:00 Opening remarks: Gail Bishop and Domagoj Vucic
5:00 – 5:40 Vishva Dixit, Genentech - "New Ways to Die: caspases, kinases and eveything in-between"
5:40 – 6:20 Hao Wu, Harvard Medical School - "Structural Elucidation of Supramolecular Complexes in Immunity"

6:30 - 7:30 pm, Dinner

7:30 - 9:00 pm, Welcome reception

 

June 4th

7:30 - 8:30 am, Breakfast

8:30 am, TNFR superfamily and cell death mechanisms

Chairs: Junying Yuan and Peter Vandenabeele

 
8:30 – 8:55 Junying Yuan, Harvard University - "Regulation of RIPK1 activation in neurodegenerative diseases associated with aging"
8:55 – 9:10 James Murphy, WEHI, Australia - "Pseudo Echo: viral mimics of the pseudokinase MLKL subvert cell death by necroptosis"
9:10 – 9:25 Pratyusha Mandal, Emory - "RIPK3 drives inflammation and lethality during sepsis independently of necroptosis"
9:25 – 9:50 Manolis Pasparakis, University of Cologne, Germany - "TNFR1 signalling in cell death and inflammation"
9:50 – 10:15 Coffee and Tea break
10:15 – 10:40 Pascal Meier, ICR, UK - "Harnessing TNF-mediated anti-tumour immunity to treat soft tissue sarcomas"
10:40 – 10:55 Adrian Ting, Icahn Shcool of Medicine - "Sensitivity to TNF-induced ripoptocide crucially mediates murine cardiac allograft rejection"
10:55 – 11:10 Inna Lavrik, Otto von Guericke University, Germany - "Dissecting molecular mechanisms of caspase-8 activation via pharmacological targeting of caspase-8/c-FLIPL heterodimer"
11:10 – 11:35 Francis Chan, Duke University - "Paradoxical Roles of RIP Kinases in Injury-Induced Inflammation"
11:35 – 12:00 Marion MacFarlane, University of Cambridge, UK - "Molecular Architecture of FADD:Caspase-8 Signalling Complexes and control of Life/Death Decisions"

12:00 – 1:00 pm, Lunch

1:15 pm, Post-translational modifications in TNFR superfamily signaling

Chairs: John Silke and Henning Walczak

 
1:15 – 1:40 John Silke, WEHI, Australia - "Time for another break: more on the role of RIPK1 cleavage in inflammation"
1:40 – 2:05 Richard Siegel, Novartis - "TNFR signalling – from super-resolution imaging to therapeutic receptor antagonism"
2:05 – 2:20 Alexander Poltorak, Tufts University - "cFLIP protects macrophages from LPS-induced cell death"
2:20 – 2:35 Arne Martens, VIB, Belgium - "The ubiquitin binding function of A20 is critical for controlling inflammation in vivo"
2:35 – 3:00 Henning Walczak, UCL Cancer Institute, UK - “Cell death-dependent inflammation and inflammatory disease: death beyond TNF”
3:00 – 3:15 Lynn Wong, University of Zurich, Switzerland - "TNFR2 induced priming of NLRP3-inflammasome via RIPK1 leads to pyroptosis in XIAP deficient cells"

3:15 – 3:45 pm Coffee and Tea break

3:45 pm, New concepts in TNFR superfamily signaling

Chairs: David Wallach and Kim Newton

 
3:45 – 4:10 Kim Newton, Genentech - "The interplay between Caspase-8 and RIPK1 during development"
4:10 – 4:25 Adi Murthy, Genentech - "Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins"
4:25 – 4:40 Philippe Bouillet, WEHI, Australia - "Impaired post-transcriptional regulation of TNF causes developmental defects and inflammatory diseases"
4:40 – 4:55 Sandra Zinkel, Vanderbilt University - "Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure"
4:55 – 5:10 Sjoerd van Wijk, Goethe University, Germany - "Single-molecule imaging of the plasma membrane TNFR1 equilibrium reveals novel roles for the Pre-Ligand Assembly Domain in ligand-independent TNFR1 clustering"
5:10 – 5:35 Sergei Nedospasov, Russian Academy of Sciences, Russia - "Distinct modes of TNF signaling in health and disease"

5:35 – 6:05 pm, Lightning Poster session talks 1

8 selected poster presenters, each 2.5 min  

Ali Abdul-Sater, Dieter Adam, Christopher Barnum, Nicolas Bidere, Fiona Carty, Leslie Chavez-Galan, Tinneke Delvaeye, Daniel Giles

6:05 – 7:05 pm, Dinner

7:30 – 9:30 pm, Poster session 1 with wine, beer and desserts

 

June 5th

7:30 – 8:30 pm Breakfast

8:30 am, The TNFR superfamily and lymphocyte function

Chairs: Fabienne Mackay and Jennifer Gommerman

 
8:30 – 8:55 Fabienne Mackay, University of Melbourne, Australia - "A novel cytokine-controlled immune checkpoint in Chronic Lymphocytic Leukaemia"
8:55 – 9:20 Gail Bishop, University of Iowa - "TRAF3 as a B cell survival regulator and tumor suppressor"
9:20 – 9:45 Neal Alto, UT Southwestern - "Non-canonical NF-kB gene regulation by the SIX family transcription factors"
9:45 – 10:00 Wai Lin, Sanford Burnham Institute - "HVEM Regulates the Type I IFN restricting the IL-1β response during MHV68 infection"
10:00 – 10:25 Coffee and Tea break
10:25 – 10:50 Jennifer Gommerman, University of Toronto, Canada - "BAFF, IgA and Autoimmunity"
10:50 – 11:05 Kate Lambertsen, University of Southern Denmark, Denmark - "Deficiency in TNF impairs neurogenesis and alters the number of microglia and neurons in the cerebral cortex"
11:05 – 11:20 Roberta Brambilla, University of Miami - "Astroglial TNFR2 signaling is implicated in the regulation of learning, memory and anxiety"
11:20 – 11:35 Tina Arkee, University of Iowa - "TRAF3-mediated regulation of the T cell receptor complex"
11:35 – 11:50 Rudolf Lucas, Medical College of Georgia - "A novel strategy to blunt deleterious TNF actions in glomerulonephritis"

12:00 – 1:00 pm, Round Table with Science Signaling (John Foley), FEBS Journal (Seamus Martin) and EMBO Journal (Elisabetta Argenzio) Editors to discuss publishing high impact papers (buffet lunch will be served for attendees)

12:00 – 1:00 pm, Lunch

1:15 pm, TNFR superfamily in tissue homeostasis and immunity

Chairs: Jane Grogan and Elisabetta Argenzio

 
1:15 – 1:40 Jane Grogan, Genentech - "Role for OX40 and other TNFRSF on Specific T cell Subsets within Tumors"
1:40 – 1:55 Lorraine O’Reilly, WEHI, Australia - "Loss of NF-kB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner"
1:55 – 2:10 Bertrand Huard, University Grenoble, France - "The anti-inflammatory response induced by CNS-derived APRIL in multiple sclerosis and beyond"
2:10 – 2:35 Domagoj Vucic, Genentech - "Regulation of Inflammatory Cell Death Signaling by RIP Kinases"
2:35 – 2:50 Denise Faustman, Massachusetts General/Harvard - "Antagonism of the TNF Superfamily of Receptors: Focus on Novel Functional Antibodies with Preference for the Tumor Microenvironment"
2:50 – 3:15 Wenjun Ouyang, Amgen - "Single cell RNAseq data reveal regulatory pathways including TNF family members in cancers"
 

3:15 – 3:45 pm, Coffee and Tea break

3:45 pm, The TNFR superfamily and inflammation

Chairs: Carl Ware and Seamus Martin

 
3:45 – 4:10 Seamus Martin, Trinity College Dublin, Ireland - "Cell Stress and Inflammation"
4:10 – 4:35 Pascal Schneider, University of Lausanne, Switzerland - "Biochemical and clinical aspects of the TNF family ligand Ectodysplasin A"
4:35 – 4:50 Rana Herro, La Jolla Institute for Allergy and Immunology - "Shedding LIGHT and TL1A on fibrosis"
4:50 – 5:05 Yves Dondelinger, University of Ghent, Belgium - "Serine 25 phosphorylation inhibits RIPK1 kinase activity and prevents RIPK1-dependent cell death in models of infection and inflammation"
5:05 – 5:30 Carl Ware, Sanford Burnham Prebys Institute, La Jolla - "The HVEM Network: at the Intersection of Infection, Cancer and Autoimmunity"

5:30 – 6:00 pm, Lightning Poster session talks 2

9 selected poster presenters, each 2.5 min

Bohdan Harvey, Matthias Kist, Hanzeng Li, Minna Christiansen Lund, Katsuhiro Sasaki, Daehyeon Seong, Ganesh Viswanathan, Masayuki Yamashita, Jieqiong Zhang

6:00 – 7:00 pm, Dinner

7:30 – 9:30 pm, Poster session 2 with wine, beer and desserts

 

June 6th

7:30 – 8:30 pm Breakfast

8:30 am, Manipulation of TNFR superfamily signaling pathways  

Chairs: Tania Watts and Shao-Cong Sun

 
8:30 – 8:55 Tania Watts, University of Toronto, Canada - "Signal 4- a TNFR superfamily-dependent checkpoint for anti-viral T cell accumulation and formation of tissue resident memory T cells"
8:55 – 9:10 Paola Betancur, UCSF - "Protecting Tumor Cells from the Innate Immune System: A Novel Role for the TNF-NFKB1 Inflammatory Signaling Pathway"
9:10 – 9:25 Sergio Lavilla Alonso, Genmab, Netherlands - "Potent DR5 agonist activity of HexaBody®-DR5/DR5 through hexamer-induced DR5 hyperclustering and independent of Fc-gamma receptor binding"
9:25 – 9:40 Eugene Varfolomeev, Genentech - "RIP1 inhibition blocks inflammatory diseases"
9:40 – 10:05 Coffee and Tea break
10:05 – 10:30 Shao-Cong Sun, University of Texas MD, Anderson Cancer Center - "Regulation of noncanonical NF-kB pathway by TRAFs: new insight into signaling mechanisms and functions"
10:30 – 10:45 Conglei Li, University of Toronto, Canada - "Perinatal Programming of Mucosal Stromal Cell Identity by the Lymphotoxin Pathway Regulates B Cell Responses in the Adult"
10:45 – 11:00 Dagmar Kulms, Technical University Dresden, Germany - "Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma"
11:00 – 11:15 Eva Vanamee, Fusion Bio - "Fusion Ligand Platform for Improved Immunotherapies"
11:15 – 11:30 Michel Cannieux, IDT - "Latest product developments to IDT’s CRIPSR product line: Enzyme engineering and off-target detection"

11:45 – 12:45 pm, Lunch

1:00 pm, TNFR superfamily signaling pathways and disease pathogenesis

Chairs: Michael Croft and Pascal Schneider

 
1:00 – 1:25 Robert Stoffel, AbbVie - "Anti-TNF Glucocorticoid Antibody Drug Conjugate for the Treatment of Autoimmune Diseases"
1:25 – 1:50 Cristina Vazquez-Mateo, EMD Serono - "Targeting BLyS and APRIL with atacicept in Systemic lupus erythematosus (SLE) and IgA Nephropathy (IgAN)"
1:50 – 2:05 Matija Zelic, Sanofi - "Assessing the impact of RIPK1 activation on microglial turnover in neuroinflammation and neurodegeneration"
2:05 – 2:30 Michael Croft, La Jolla Institute for Immunology - "Is Functional Overlap of TNF Family Molecules a Problem for Effective Therapeutic Targeting in Autoimmune or Inflammatory Disease?"

2:30 – 6:30 pm, Free time

6:30 – 8:30 pm, Conference dinner: California Coastal Fair including Concluding remarks and Poster awards, Chairs: Gail Bishop and Domagoj Vucic

9:00 – 11:00 am, Live music and dancing

 

June 7th, Departure 

7:30 – 8:30 am Breakfast