17th TNF conference 2019 – preliminary program

June 3rd, Arrival

any time after 2 pm, Registration

4:40 pm, Plenary session

Chairs: Gail Bishop and Domagoj Vucic

 
4:40 – 5:00 Opening remarks: Gail Bishop and Domagoj Vucic
5:00 – 5:40 Vishva Dixit, Genentech - "New Ways to Die: caspases, kinases and eveything in-between"
5:40 – 6:20 Hao Wu, Harvard Medical School - "Structural Elucidation of Supramolecular Complexes in Immunity"

6:30 - 7:30 pm, Dinner

7:30 - 9:00 pm, Welcome reception

 

June 4th

7:30 - 8:30 am, Breakfast

8:30 am, TNFR superfamily and cell death mechanisms

Chairs: Junying Yuan and Peter Vandenabeele

 
8:30 – 8:55 Junying Yuan, Harvard University - "Regulation of RIPK1 activation in neurodegenerative diseases associated with aging"
8:55 – 9:10 James Murphy, WEHI, Australia - "Pseudo Echo: viral mimics of the pseudokinase MLKL subvert cell death by necroptosis"
9:10 – 9:25 Pratyusha Mandal, Emory - "RIPK3 drives inflammation and lethality during sepsis independently of necroptosis"
9:25 – 9:50 Manolis Pasparakis, University of Cologne, Germany - "TNFR1 signalling in cell death and inflammation"
9:50 – 10:15 Coffee and Tea break
10:15 – 10:40 Pascal Meier, ICR, UK - "Harnessing TNF-mediated anti-tumour immunity to treat soft tissue sarcomas"
10:40 – 10:55 Adrian Ting, Icahn Shcool of Medicine - "Sensitivity to TNF-induced ripoptocide crucially mediates murine cardiac allograft rejection"
10:55 – 11:10 Inna Lavrik, Otto von Guericke University, Germany - "Dissecting molecular mechanisms of caspase-8 activation via pharmacological targeting of caspase-8/c-FLIPL heterodimer"
11:10 – 11:35 Francis Chan, Duke University - "Paradoxical Roles of RIP Kinases in Injury-Induced Inflammation"
11:35 – 12:00 Marion MacFarlane, University of Cambridge, UK - "Molecular Architecture of FADD:Caspase-8 Signalling Complexes and control of Life/Death Decisions"

12:00 – 1:00 pm, Lunch

1:15 pm, Post-translational modifications in TNFR superfamily signaling

Chairs: John Silke and Henning Walczak

 
1:15 – 1:40 John Silke, WEHI, Australia - "Time for another break: more on the role of RIPK1 cleavage in inflammation"
1:40 – 2:05 Richard Siegel, Novartis - "TNFR signalling – from super-resolution imaging to therapeutic receptor antagonism"
2:05 – 2:20 Alexander Poltorak, Tufts University - "cFLIP protects macrophages from LPS-induced cell death"
2:20 – 2:35 Arne Martens, VIB, Belgium - "The ubiquitin binding function of A20 is critical for controlling inflammation in vivo"
2:35 – 3:00 Henning Walczak, UCL Cancer Institute, UK - “Cell death-dependent inflammation and inflammatory disease: death beyond TNF”
3:00 – 3:15 Lynn Wong, University of Zurich, Switzerland - "TNFR2 induced priming of NLRP3-inflammasome via RIPK1 leads to pyroptosis in XIAP deficient cells"

3:15 – 3:45 pm Coffee and Tea break

3:45 pm, New concepts in TNFR superfamily signaling

Chairs: David Wallach and Kim Newton

 
3:45 – 4:10 Kim Newton, Genentech - "The interplay between Caspase-8 and RIPK1 during development"
4:10 – 4:25 Adi Murthy, Genentech - "Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins"
4:25 – 4:40 Philippe Bouillet, WEHI, Australia - "Impaired post-transcriptional regulation of TNF causes developmental defects and inflammatory diseases"
4:40 – 4:55 Sandra Zinkel, Vanderbilt University - "Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure"
4:55 – 5:10 Sjoerd van Wijk, Goethe University, Germany - "Single-molecule imaging of the plasma membrane TNFR1 equilibrium reveals novel roles for the Pre-Ligand Assembly Domain in ligand-independent TNFR1 clustering"
5:10 – 5:35 Sergei Nedospasov, Russian Academy of Sciences, Russia - "Distinct modes of TNF signaling in health and disease"

5:35 – 6:05 pm, Lightning Poster session talks 1

9 selected poster presenters, each 2.5 min  

6:05 – 7:05 pm, Dinner

7:30 – 9:30 pm, Poster session 1 with wine, beer and desserts

 

June 5th

7:30 – 8:30 pm Breakfast

8:30 am, The TNFR superfamily and lymphocyte function

Chairs: Fabienne Mackay and Jennifer Gommerman

 
8:30 – 8:55 Fabienne Mackay, University of Melbourne, Australia - "A novel cytokine-controlled immune checkpoint in Chronic Lymphocytic Leukaemia"
8:55 – 9:20 Gail Bishop, University of Iowa - "TRAF3 as a B cell survival regulator and tumor suppressor"
9:20 – 9:45 Neal Alto, UT Southwestern - "Non-canonical NF-kB gene regulation by the SIX family transcription factors"
9:45 – 10:00 Wai Lin, Sanford Burnham Institute - "HVEM Regulates the Type I IFN restricting the IL-1β response during MHV68 infection"
10:00 – 10:25 Coffee and Tea break
10:25 – 10:50 Jennifer Gommerman, University of Toronto, Canada - "BAFF, IgA and Autoimmunity"
10:50 – 11:05 Kate Lambersten, University of Southern Denmark, Denmark - "Deficiency in TNF impairs neurogenesis and alters the number of microglia and neurons in the cerebral cortex"
11:05 – 11:20 Roberta Brambilla, University of Miami - "Astroglial TNFR2 signaling is implicated in the regulation of learning, memory and anxiety"
11:20 – 11:35 Tina Arkee, University of Iowa - "TRAF3-mediated regulation of the T cell receptor complex"
11:35 – 11:50 Rudolf Lucas, Medical College of Georgia - "A novel strategy to blunt deleterious TNF actions in glomerulonephritis"

12:00 – 1:00 pm, Round Table with Science Signaling (John Foley) and EMBO Journal (Elisabetta Argenzio) Editors to discuss publishing high impact papers (buffet lunch will be served for attendees)

12:00 – 1:00 pm, Lunch

1:15 pm, TNFR superfamily in tissue homeostasis and immunity

Chairs: Jane Grogan and Elisabetta Argenzio

 
1:15 – 1:40 Jane Grogan, Genentech - "Role for OX40 and other TNFRSF on Specific T cell Subsets within Tumors"
1:40 – 1:55 Lorraine O’Reiley, WEHI, Australia - "Loss of NF-kB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner"
1:55 – 2:10 Huard Bertrand, University Grenoble, France - "The anti-inflammatory response induced by CNS-derived APRIL in multiple sclerosis and beyond"
2:10 – 2:35 Domagoj Vucic, Genentech - "Regulation of Inflammatory Cell Death Signaling by RIP Kinases"
2:35 – 2:50 Denise Faustman, Massachusetts General/Harvard - "Antagonism of the TNF Superfamily of Receptors: Focus on Novel Functional Antibodies with Preference for the Tumor Microenvironment"
2:50 – 3:15 Wenjun Ouyang, Amgen - "Single cell RNAseq data reveal regulatory pathways including TNF family members in cancers"
 

3:15 – 3:45 pm, Coffee and Tea break

3:45 pm, The TNFR superfamily and inflammation

Chairs: Carl Ware and Seamus Martin

 
3:45 – 4:10 Seamus Martin, Trinity College Dublin, Ireland - "Cell Stress and Inflammation"
4:10 – 4:35 Pascal Schneider, University of Lausanne, Switzerland - "Biochemical and clinical aspects of the TNF family ligand Ectodysplasin A"
4:35 – 4:50 Rana Herro, La Jolla Institute for Allergy and Immunology - "Shedding LIGHT and TL1A on fibrosis"
4:50 – 5:05 Yves Dondelinger, University of Ghent, Belgium - "Serine 25 phosphorylation inhibits RIPK1 kinase activity and prevents RIPK1-dependent cell death in models of infection and inflammation"
5:05 – 5:30 Carl Ware, Sanford Burnham Prebys Institute, La Jolla - "The HVEM Network: at the Intersection of Infection, Cancer and Autoimmunity"

5:30 – 6:00 pm, Lightning Poster session talks 2

9 selected poster presenters, each 2.5 min

6:00 – 7:00 pm, Dinner

7:30 – 9:30 pm, Poster session 2 with wine, beer and desserts

 

June 6th

7:30 – 8:30 pm Breakfast

8:30 am, Manipulation of TNFR superfamily signaling pathways  

Chairs: Tania Watts and Shao-Cong Sun

 
8:30 – 8:55 Tania Watts, University of Toronto, Canada - "Signal 4- a TNFR superfamily-dependent checkpoint for anti-viral T cell accumulation and formation of tissue resident memory T cells"
8:55 – 9:10 Paola Bentancur, UCSF - "Protecting Tumor Cells from the Innate Immune System: A Novel Role for the TNF-NFKB1 Inflammatory Signaling Pathway"
9:10 – 9:25 Sergio Lavilla Alonso, Genmab, Netherlands - "Potent DR5 agonist activity of HexaBody®-DR5/DR5 through hexamer-induced DR5 hyperclustering and independent of Fc-gamma receptor binding"
9:25 – 9:40 Eugene Varfolomeev, Genentech - "RIP1 inhibition blocks inflammatory diseases"
9:40 – 10:05 Coffee and Tea break
10:05 – 10:30 Shao-Cong Sun, University of Texas MD, Anderson Cancer Center - "Regulation of noncanonical NF-kB pathway by TRAFs: new insight into signaling mechanisms and functions"
10:30 – 10:45 Conglei Li, University of Toronto, Canada - "Perinatal Programming of Mucosal Stromal Cell Identity by the Lymphotoxin Pathway Regulates B Cell Responses in the Adult"
10:45 – 11:00 Dagmar Kulms, Technical University Dresden, Germany - "Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma"
11:00 – 11:15 Eva Vanamee, Fusion Bio - "Fusion Ligand Platform for Improved Immunotherapies"
11:15 – 11:30 Michel Cannieux, IDT - "Latest product developments to IDT’s CRIPSR product line: Enzyme engineering and off-target detection"

11:45 – 12:45 pm, Lunch

1:00 pm, TNFR superfamily signaling pathways and disease pathogenesis

Chairs: Michael Croft and Pascal Schneider

 
1:00 – 1:25 Robert Stoffel, AbbVie - "Anti-TNF Glucocorticoid Antibody Drug Conjugate for the Treatment of Autoimmune Diseases"
1:25 – 1:50 Cristina Vazquez-Mateo, EMD Serono - "Targeting BLyS and APRIL with atacicept in Systemic lupus erythematosus (SLE) and IgA Nephropathy (IgAN)"
1:50 – 2:05 Matija Zelic, Sanofi - "Assessing the impact of RIPK1 activation on microglial turnover in neuroinflammation and neurodegeneration"
2:05 – 2:30 Michael Croft, La Jolla Institute for Immunology - "Is Functional Overlap of TNF Family Molecules a Problem for Effective Therapeutic Targeting in Autoimmune or Inflammatory Disease?"

2:30 – 6:30 pm, Free time

6:30 – 8:30 pm, Conference dinner: California Coastal Fair including Concluding remarks and Poster awards, Chairs: Gail Bishop and Domagoj Vucic

9:00 – 11:00 am, Live music and dancing

 

June 7th, Departure 

7:30 – 8:30 am Breakfast